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- Four biovars of C. trachomatis cause human infection and clinical disease (trachoma, lymphogranuloma venereum, urogenital infections, etc.).
- Obligate intracellular parasite, requires eukaryotic host cell for ATP; cultivated only within cell cultured system.
- 2 distinct mophologic cycles: elementary body (metabolically inert extracellular infectious particle) and reticulate body (intracellular, replicating form).
- Commonest syndromes in HIV practice involve C. trachomatis serovars infecting columnar or cuboidal epithelial surfaces.