Avascular necrosis is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

PATHOGENS

  • In general population, ethanol use and glucorticoid use account for 90% of cases. Other associated conditions include lupus, sickle cell disease, organ transplantation, antiphospholipid antibodies, trauma, radiation.
  • In HIV+ patients, incidence is 100x that of general population. Asymptomatic disease found in 6%.
  • Risk factors include low CD4 nadir, prior AIDS-defining illness, dyslipidemia, and traditional risk factors. Majority of patients exposed to glucocorticoids or megestrol.
  • Direct role of ART controversial. Pharmacologic inhibition of CYP3A4 may increase exogenous glucocorticoid exposure.
  • Exact pathogenesis is uncertain. Above risk factors may predispose to compromised local blood flow.

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: March 10, 2011

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Avascular necrosis ID - 545016 A1 - Brown,Todd,M.D., Ph.D. Y1 - 2011/03/10/ PB - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545016/all/Avascular_necrosis ER -