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- In general population, ethanol use and glucorticoid use account for 90% of cases. Other associated conditions include lupus, sickle cell disease, organ transplantation, antiphospholipid antibodies, trauma, radiation.
- In HIV+ patients, incidence is 100x that of general population. Asymptomatic disease found in 6%.
- Risk factors include low CD4 nadir, prior AIDS-defining illness, dyslipidemia, and traditional risk factors. Majority of patients exposed to glucocorticoids or megestrol.
- Direct role of ART controversial. Pharmacologic inhibition of CYP3A4 may increase exogenous glucocorticoid exposure.
- Exact pathogenesis is uncertain. Above risk factors may predispose to compromised local blood flow.
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Last updated: March 10, 2011
Brown, Todd T. "Avascular Necrosis." Johns Hopkins HIV Guide, 2011. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545016/all/Avascular_necrosis.
Brown TT. Avascular necrosis. Johns Hopkins HIV Guide. 2011. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545016/all/Avascular_necrosis. Accessed November 21, 2019.
Brown, T. T. (2011). Avascular necrosis. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545016/all/Avascular_necrosis
Brown TT. Avascular Necrosis [Internet]. In: Johns Hopkins HIV Guide. ; 2011. [cited 2019 November 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545016/all/Avascular_necrosis.
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T1 - Avascular necrosis
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