- Treatment of HIV infection in combination with other ARVs.
$10.26 per tab
10 mg/mL (240ml bottle)
$161.78 (per 240ml)
ABC 300 mg + AZT 300 mg + 3TC 150 mg
$26.81 per tab
ABC + 3TC
ABC 600 mg + 3TC 300 mg
$35.78 per tab
Kivexa (brand name available in Europe)
ABC + 3TC
ABC 600 mg + 3TC 300 mg
*Prices represent cost per unit specified, are representative of "Average Wholesale Price" (AWP).
^Dosage is indicated in mg unless otherwise noted.
USUAL ADULT DOSING
Pill burden: 2 pills/d (Ziagen, Trizivir) or 1 pill/d (Epzicom, Kivexa)
- ABC 300 mg PO twice-daily with or without food (as Ziagen or Trizivir).
- ABC 600 mg PO once-daily with or without food (as Ziagen, Epzicom, or Kivexa).
USUAL PEDIATRIC DOSING
- Neonate: NOT approved for < 3 months.
- Infants ≥ 3 months: 8 mg/kg/dose (max 300mg) PO twice daily
- In clinically stable patients with undetectable viral load and stable CD4 count on twice daily dosing of ABC, can consider 16 mg/kg/dose (max 600mg) once daily ABC.
- Children ≥14 kg: (weight based dosing using scored 300mg tablet)
- 14 to 21 kg: 1/2 tab (150mg) twice daily
- > 21 to < 30kg: 1/2 tab (150mg) in the AM, and 1 tab (300mg) in the PM
- ≥ 30kg: 1 tab (300mg) twice daily
- Adolescents (≥16 y/o): 300mg twice daily OR 600mg once daily
PEDIATRIC RENAL DOSING
No renal dosage adjustment necessary.
OTHER PEDIATRIC INFORMATION
- Switching from twice daily to once daily ABC has been studied in 3 small clinical trials (PENTA 15, PENTA 13, and Arrow) of HIV infected children who had undetectable viral loads and were clinically stable. The studies showed similar AUC(0-24) between twice daily and once daily dosing, however, once daily dosing resulted in lower trough concentrations in younger children. After switching to once daily ABC, most children had good clinical outcomes.
DOSING FOR GLOMERULAR FILTRATION OF 50-80
DOSING FOR GLOMERULAR FILTRATION OF 10-50
DOSING FOR GLOMERULAR FILTRATION OF <10 ML/MIN
DOSING IN HEMODIALYSIS
DOSING IN PERITONEAL DIALYSIS
No data-Usual dose likely
DOSING IN HEMOFILTRATION
No data-Usual dose likely
ADVERSE DRUG REACTIONS
- Symptoms reported by 7% of patients in clinical trials (8-11% when given with AZT)
- Abdominal pain
- HYPERSENSITIVITY REACTION (HSR): noted in ~4% of pts: fever, rash, fatigue, malaise, GI Sx, myalgias, and arthralgias.
- Over 93% occur within first 6 wks of therapy, with median time of onset of 11 days.
- Requires discontinuation, but can continue ABC with close monitoring until dx certain or likely (sx generally worsen with each dose).
- DO NOT RE-CHALLENGE, since anaphylactic-like reaction and death reported.
- HSR more common in Caucasians and associated with HLA-DR7, HLA-DQ3, and HLA-B*5701 haplotypes.
- Genetic testing for HLA-B*5701 (cost $70-80) virtually eliminates risk of HSR, though patients should still be counseled about HSR before initiation.
- ABC should NOT be given to pts with positive test.
- MITOCHONDRIAL TOXICITY: lipoatrophy and lactic acidosis with hepatic steatosis described with NRTI class, although most common with ddI, d4T, ddC, and AZT.
- Unclear whether it occurs at all with ABC, since ABC is one of the least likely NRTIs to cause mitochondrial toxicity in vitro.
- Possible increased risk of myocardial infaction (see D:A:D and SMART references)
Not a substrate, inducer, or inhibitor of CYP3A4. No interaction likely with PIs, NNRTIs, MVC, and RAL. ABC metabolized by alcohol dehydrogenase and glucoronyl transferase.
Effect of Interaction
3TC AUC decreased by 15%.
Not clinically significant. Use standard dose.
ABC AUC increased by 41%.
Clinical significance unknown. No dose adjustment recommended.
No significant interaction.
Use standard dose.
ABC AUC was decreased by 5%(NS).
Administer ABC with or without food.
Methadone clearance increased by 23%;
Monitor for methadone withdrawal, but dose adjustment unlikely to be necessary.
Decreased EVR to HCV treatment.
Suboptimal virologic suppression when ABC/TDF/3TC once daily was used as a triple nucleoside regimen without PIs or NNRTIs. However, preliminary analysis of ABC/AZT/3TC with TDF as nucleoside regimen did not show similar suboptimal results, and no evidence of drug interaction.
Decreased ABC AUC by 40%.
Clinical significance unknown. Active intracellular carbovir triphosphate not measured. Use standard dose.
- 74V: Intermediate resistance to ABC and ddI. Most common mutation to be selected by ABC/3TC-containing regimens without thymidine analog. M184V further decreases susceptibility.
- 65R: Low-level resistance, and intermediate resistance to ddI, TDF, 3TC, FTC. Can be selected by ABC/3TC-containing regimens without thymidine analog, though 74V more common. Intermediate ABC and ddI resistance with 65R + 184V. M184V partially restores TDF susceptibility
- 184V + ≥3 TAMs: Intermediate-to high-level resistance. Greater ABC resistance with 41L/210W/215Y TAM pathway than with 67N/70R/219 pathway. High-level resistance with≥4 TAMs
- 115F: Can be selected by ABC, and causes low-level resistance. Intermediate resistance with 115F + 184V.
- 184V: Can cause low-level loss of susceptibility to ABC, but by itself is not associated with clinically relevant resistance.
Intracellular phosphorylation to active carbovir triphosphate, which competitively inhibits HIV DNA polymerase.
Well absorbed with 83% oral bioavailability.
Metabolism and Excretion
81% metabolized by alcohol dehydrogenase and glucuronyl transferase with renal excretion of metabolites; 16% recovered in stool and 1% unchanged in urine.
Cmax, Cmin, and AUC
Mean steady-state Cmax=3mcg/mL; AUC=6 mcg hr/mL. Intracellular levels of carbovir triphosphate 100 FM/million cells.
Serum: 1.5 hrs; intercellular (carbovir triphosphate):-12-20hrs.
DOSING FOR DECREASED HEPATIC FUNCTION
Usual dose or 200 mg twice daily (limited clinical data).
Category C: rodent studies demonstrated placental passage. Teratogenic in rodent studies resulting in anasarca, skeletal malformation at 1000 mg/kg dose (35x human therapeutic levels) during organogenesis. However, rabbit studies using 8.5x human therapeutic levels did not result in fetal malformation. No adequate human data, placental passage was 32-66%.
BREAST FEEDING COMPATIBILITY
No human data. Breast feeding is not recommended in the U.S in order to avoid post-natal transmission of HIV to the child, who may not yet be infected.
Trizivir (AZT/3TC/ABC) equivalent to unboosted IDV-based HAART regimen in pts with baseline VL < 100,000, but inferior to EFV-based HAART regimens. Since Trizivir (without a PI or NNRTI) is inferior to gold standard EFV-based regimen, it is recommended by the DHHS Guidelines only as alternative regimen when PI- or NNRTI-based regimens cannot be used. Addition of ABC to AZT/3TC/EFV did not improve virologic response in ART-naive patients. HLA-B*5701 should be ordered in all pts before starting ABC, and ABC should not be given to those who test positive. Recent data suggest decreased virologic response compared to TDF/FTC in pts with baseline VL >100,000, and possible increased risk of MI.
- Pros: One of most potent NRTIs, with VL reduction of 1.5-2.0 logs in monotherapy; good data on ABC/3TC as a well tolerated and effective once-daily dual-NRTI backbone; development of 74V mutation with failure may allow sequencing to TDF, though clinical data lacking; coformulated with 3TC (Epzicom, Kivexa) and with AZT/3TC (Trizivir); HLA B*5701 pre-screening essentially eliminates HSR risks discussed below.
- Cons: Hypersensitivity reaction; requires pre-treatment screening and counseling/education; can be fatal with rechallenge; shorter intracellular half-life than TDF, and no susceptibility benefit with M184V. Less long-term data than with TDF. May be inferior compared to TDF in pts with baseline VL >100,000 c/mL (ACTG 5202). May increase risk of cardiovascular disease in pts with risk factors (D:A:D and SMART studies).
- Paediatric European Network for Treatment of AIDS (PENTA): Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months. Antivir Ther 15:297, 2010 [PMID:20516550]
- Sax PE et al: Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy. N Engl J Med 361:2230, 2009 [PMID:19952143]
Comment: Randomized controled trial compared TDF/FTC and ABC/3TC in combination with EFV or boosted ATV.At a median follow-up of 60 weeks, among pts with VL >100K c/mL, the time to virologic failure was significantly shorter in the ABC/3TC group than in the TDF/FTC group (hazard ratio, 2.33; 95% confidence interval, 1.46 to 3.72; P<0.001), 57 virologic failures (14%) were observed in the ABC/3TC group versus 26 (7%) in the TDF/FTC group. In pts with VL <100K c/mL, there was no significant difference in time to virological failure between groups.
- D:A:D Study Group et al: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 371:1417, 2008 [PMID:18387667]
Comment: A retrospective review of D:A:D observational cohort for cardiovascular disease risks associated with NRTI use included 33,347 pts (157,912 pt-yrs of follow-up). There were 517 MIs, including 192 in pts receiving ABC-containing regimens. After adjusting for confounding risk factors, relative risk for ABC use within last 6 months was 1.9 (95% CI 1.5-2.5). There was also increased risk associated with ddI treatment, but not d4T or AZT. Greatest risk (and greatest increased risk) in pts with risk factors for cardiovascular disease. Pathophysiologic mechanism of this effect, if real, has not been identified. Other studies have not shown this risk, but they may have been under powered to show a risk of an infrequent toxicity. However, the usual caveats with observational studies apply.
- Gulick RM et al: Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial. JAMA 296:769, 2006 [PMID:16905783]
Comment: Continuation of ACTG 5095 compared AZT/3TC/EFV to AZT/ABC/3TC/EFV in ART-naive pts. No significant differences between 3vs 4-drug regimens; approximately 80% of pts had VL < 50 through 3 yrs. 10% treated with AZT/3TC/ABC/EFV had ABC HSR, vs. 7% on AZT/3TC/EFV.
- Gallant JE et al: Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects. J Infect Dis 192:1921, 2005 [PMID:16267763]
Comment: High rate of virologic failure in the TDF+ABC+3TC arm, with 49% experiencing virologic failure compared to 5.4% of pts taking EFV. Among TDF-treated pts for whom virologic data are available, 64% had both the K65R and M184V mutations and 36% had M184V alone. TDF/ABC/3TC is not recommended as a triple-NRTI regimen, and data minimal for use with a 4th agent.
- Moyle GJ et al: Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviral-naive HIV-infected adults: results of the Ziagen Once Daily in Antiretroviral Combination Study. J Acquir Immune Defic Syndr 38:417, 2005 [PMID:15764958]
Comment: EFV + once- or twice-daily ABC as part of an ABC/3TC backbone were equivalent, with 66% and 68% of pts achieving VL <50, respectively.
- Bergshoeff A et al: Plasma pharmacokinetics of once- versus twice-daily lamivudine and abacavir: simplification of combination treatment in HIV-1-infected children (PENTA-13). Antivir Ther 10:239, 2005 [PMID:15865218]
Comment: The PENTA 13 cross-over PK study evaluated ABC 8mg/kg BID vs. 16mg/kg QD in 24 HIV infected children ages 2-13 years old who had undetectable/low viral loads and stable CD4 counts. Although AUC (0-24) was comparable between QD and BID dosing, Cmin of QD ABC was lower in younger children (2-6 y/o).
- DeJesus E et al: Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults. Clin Infect Dis 39:1038, 2004 [PMID:15472858]
Comment: ABC/3TC + EFV was non-inferior to AZT/3TC + EFV in a randomized, double-blind study involving 649 naive pts. Response rate (<50) through wk 48 was 70% and 69% in ABC and AZT group, respectively. Pts on ABC/3TC had less nausea, vomiting, fatigue, and anemia than pts taking AZT, but more HSR. ABC/3TC associated with greater increase in CD4 (209 vs 155) and CD4%.
- Gulick RM et al: Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med 350:1850, 2004 [PMID:15115831]
Comment: Compared triple-NRTI regimen of AZT/3TC/ABC with 2 EFV-containing regimens, AZT/3TC + EFV and AZT/3TC/ABC + EFV. Triple-NRTI arm was stopped early because of higher rate of virologic failure vs. EFV-based regimens (21% vs 10%, p <0.001). Triple NRTI regimens should only be used as alternative in pts who cannot take PI or NNRTI-based regimens.
- Mallal S et al: Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 359:727, 2002 [PMID:11888582]
Comment: This study found an extraordinary association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 alleles and HSR to ABC (OR 822 [43-15675], p<0.0001). Authors concluded that if ABC was withheld in presence of these alleles, prevalence of HSR would decrease from 9-5% to 2.5%. Positive predictive value for HSR 100%, negative predictive value 97%.
- Staszewski S et al: Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial. JAMA 285:1155, 2001 [PMID:11231744]
Comment: AZT/3TC + ABC was equivalent to AZT/3TC + unboosted IDV, with 51% in both group achieving VL <400 at 48 wks. Trend favoring IDV-based regimen in pts with baseline VL >100,000, with 45% vs 31% achieving <50 (a treatment difference -14% (95% CI, -27% to 0%). Although this trial demonstrated equivalency at <400 endpoint, the decreased potency at high VL suggests lower potency overall.
- SMART/INSIGHT and D:A:D Study Groups; Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients; AIDS; Vol. 22; pp. F17-24;
Comment: Retrospective review of 2752 pts enrolled in continous treatment arm of SMART evaluated cardiovascular (CV) disease risks associated with NRTI components of ARV regimens. CV risk factors comparable between groups: median age of 40, 73% males, 39% smokers, 7% had diabetes, and 4% with prior CV disease. Use of ABC associated with increased risk of MI (AHR = 4.3), CV-related death (AHR = 1.8), with signficantly increased risk seen in those with 5 or more CV risk factors.
- Mallal S, Phillips E, Carosi G, et al.; PREDICT-1: a novel randomised prospective study to determine the clinical utility of HLA-B*5701 screening to reduce abacavir hypersensitivity in HIV-1 infected subjects (study CNA106030); 4th IAS Conference on HIV Pathogenesis, Treatment, and Prevention, 2007, Sydney Australia;
Comment: Study randomized 1956 ABC-naive patients to standard of care or screening with HLA-B*5701 test before starting ABC. Incidence of both clinically diagnosed and immunologically confirmed HSR significantly lower in screening arm vs. control arm. No cases of immunologically confirmed HSR observed in prospective screening arm. HLA-B*5701 had a 100% sensitivity.
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