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Diabetes and Periodontal Disease

Karl J. Zeren, D.D.S.
Diabetes and Periodontal Disease is a topic covered in the Johns Hopkins Diabetes Guide.

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  • Periodontitis: a common complex chronic inflammatory disease characterized by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone).
  • In its early stages, the condition is typically asymptomatic, and many patients are unaware of the condition until it has progressed enough to result in tooth mobility.
  • There are greater than 700 species of bacteria in the oral environment and 100 billion bacteria in the oral biofilm; and is a continuous source of infectious agents that could serve as an important risk factor.
  • Periodontal pathogens alone are insufficient to provoke the disease process:a genetically ’susceptible host’ is required.
  • There is a clear ’two way’ relationship between the degree of hyperglycemia and severity of periodontitis compared with patients with normal glucose tolerance.
  • The inflammatory response is characterized by dysregulated secretion of host-derived mediators of inflammation and tissue breakdown.
  • Differences in clinical disease expression are related to both variations in pathogens and host response.

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Last updated: September 4, 2017


Zeren, Karl J. "Diabetes and Periodontal Disease." Johns Hopkins Diabetes Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547165/0/Diabetes_and_Periodontal_Disease.
Zeren KJ. Diabetes and Periodontal Disease. Johns Hopkins Diabetes Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547165/0/Diabetes_and_Periodontal_Disease. Accessed August 17, 2019.
Zeren, K. J. (2017). Diabetes and Periodontal Disease. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547165/0/Diabetes_and_Periodontal_Disease
Zeren KJ. Diabetes and Periodontal Disease [Internet]. In: Johns Hopkins Diabetes Guide. ; 2017. [cited 2019 August 17]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547165/0/Diabetes_and_Periodontal_Disease.
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