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Immunomodulating Therapies in Type 1 Diabetes

Michael Quartuccio, M.D., Clare J. Lee, M.D., MHS, Thomas Donner, M.D.
Immunomodulating Therapies in Type 1 Diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

  • Type 1 diabetes mellitus (T1DM) is an autoimmune disease.
  • Destruction of insulin producing beta-cells by T cells renders patients insulin-deficient.
  • Exogenous insulin is therefore required for T1DM management of hyperglycemia and to prevent ketoacidosis[19].
  • Several immunomodulating therapies have been investigated in research studies over the last decades with the goal of preventing, postponing or reversing the onset of T1DM by slowing or stopping the immune-mediated destruction of beta-cells.

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Last updated: September 4, 2017

Citation

Quartuccio, Michael, et al. "Immunomodulating Therapies in Type 1 Diabetes." Johns Hopkins Diabetes Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes.
Quartuccio M, Lee CJ, Donner T. Immunomodulating Therapies in Type 1 Diabetes. Johns Hopkins Diabetes Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes. Accessed May 19, 2019.
Quartuccio, M., Lee, C. J., & Donner, T. (2017). Immunomodulating Therapies in Type 1 Diabetes. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes
Quartuccio M, Lee CJ, Donner T. Immunomodulating Therapies in Type 1 Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2017. [cited 2019 May 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Immunomodulating Therapies in Type 1 Diabetes ID - 547160 A1 - Quartuccio,Michael,M.D. AU - Lee,Clare,M.D., MHS AU - Donner,Thomas,M.D. Y1 - 2017/09/04/ BT - Johns Hopkins Diabetes Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes DB - Johns Hopkins Guide DP - Unbound Medicine ER -