Immunomodulating Therapies in Type 1 Diabetes
DEFINITION
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease.
- Destruction of insulin producing beta-cells by T cells renders patients insulin-deficient.
- Exogenous insulin is therefore required for T1DM management of hyperglycemia and to prevent ketoacidosis[19].
- Several immunomodulating therapies have been investigated in research studies over the last decades with the goal of preventing, postponing or reversing the onset of T1DM by slowing or stopping the immune-mediated destruction of beta-cells.
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Last updated: September 4, 2017
Citation
Quartuccio, Michael, et al. "Immunomodulating Therapies in Type 1 Diabetes." Johns Hopkins Diabetes Guide, 2017. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes.
Quartuccio M, Lee CJ, Donner T. Immunomodulating Therapies in Type 1 Diabetes. Johns Hopkins Diabetes Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes. Accessed June 2, 2023.
Quartuccio, M., Lee, C. J., & Donner, T. (2017). Immunomodulating Therapies in Type 1 Diabetes. In Johns Hopkins Diabetes Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes
Quartuccio M, Lee CJ, Donner T. Immunomodulating Therapies in Type 1 Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2017. [cited 2023 June 02]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Immunomodulating Therapies in Type 1 Diabetes
ID - 547160
A1 - Quartuccio,Michael,M.D.
AU - Lee,Clare,M.D., MHS
AU - Donner,Thomas,M.D.
Y1 - 2017/09/04/
BT - Johns Hopkins Diabetes Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547160/all/Immunomodulating_Therapies_in_Type_1_Diabetes
DB - Johns Hopkins Guides
DP - Unbound Medicine
ER -