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- Pregabalin for painful diabetic polyneuropathy (DPN)
- Duloxetine for painful DPN
NON-FDA APPROVED USES
- Gabapentin most commonly used non-FDA approved medication for DPN.
- Non FDA-approved DPN pain medications include antidepressants, opiates or opiate-like agents and anti-epileptic medications.
- Antidepressants include tricyclic antidepressants (amitriptyline, nortriptyline) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs: venlafaxine, duloxetine).
- Antiepileptic medications include gabapentin, valproate, lamotrigine, carbamazepine, oxcarbazepine, phenytoin and lacrosamide.
- Opiate or opiate-derivative agents include oxycodone, morphine sulfate, hydromorphone, fentanyl and tramadol.
- Other agents include topical agents (lidocaine cream, lidoderm patches, capsaicin cream), neutriceuticals (Metanx, alpha-lipoic acid) and devices (spinal stimulators, transcutaneous electrical nerve stimulation).