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Treatment of Neuropathic Pain

Nima Khoshnoodi, M.D., Michael Polydefkis, M.D., M.H.S., Brian Pinto, Pharm.D.
Treatment of Neuropathic Pain is a topic covered in the Johns Hopkins Diabetes Guide.

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  • Pregabalin for painful diabetic polyneuropathy (DPN)
  • Duloxetine for painful DPN


  • Gabapentin most commonly used non-FDA approved medication for DPN[4].
  • Non FDA-approved DPN pain medications include antidepressants, opiates or opiate-like agents and anti-epileptic medications.
  • Antidepressants include tricyclic antidepressants (amitriptyline, nortriptyline) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs: venlafaxine, duloxetine).
  • Antiepileptic medications include gabapentin, valproate, lamotrigine, carbamazepine, oxcarbazepine, phenytoin and lacrosamide.
  • Opiate or opiate-derivative agents include oxycodone, morphine sulfate, hydromorphone, fentanyl and tramadol.
  • Other agents include topical agents (lidocaine cream, lidoderm patches, capsaicin cream), neutriceuticals (Metanx, alpha-lipoic acid) and devices (spinal stimulators, transcutaneous electrical nerve stimulation).

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Last updated: July 8, 2018


Khoshnoodi, Nima, et al. "Treatment of Neuropathic Pain." Johns Hopkins Diabetes Guide, 2018. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547156/all/Treatment_of_Neuropathic_Pain.
Khoshnoodi , Polydefkis M, Pinto B. Treatment of Neuropathic Pain. Johns Hopkins Diabetes Guide. 2018. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547156/all/Treatment_of_Neuropathic_Pain. Accessed June 17, 2019.
Khoshnoodi, ., Polydefkis, M., & Pinto, B. (2018). Treatment of Neuropathic Pain. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547156/all/Treatment_of_Neuropathic_Pain
Khoshnoodi , Polydefkis M, Pinto B. Treatment of Neuropathic Pain [Internet]. In: Johns Hopkins Diabetes Guide. ; 2018. [cited 2019 June 17]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547156/all/Treatment_of_Neuropathic_Pain.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Treatment of Neuropathic Pain ID - 547156 A1 - Khoshnoodi, Nima,M.D. AU - Polydefkis,Michael,M.D., M.H.S. AU - Pinto,Brian,Pharm.D. Y1 - 2018/07/08/ BT - Johns Hopkins Diabetes Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547156/all/Treatment_of_Neuropathic_Pain DB - Johns Hopkins Guide DP - Unbound Medicine ER -