FDA

• Pregabalin for painful diabetic polyneuropathy (DPN)

• Duloxetine for painful DPN

NON-FDA APPROVED USES

• Gabapentin most commonly used non-FDA approved medication for DPN[4].

• Non FDA-approved DPN pain medications include antidepressants, opiates or opiate-like agents and anti-epileptic medications.

• Antidepressants include tricyclic antidepressants (amitriptyline, nortriptyline) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs: venlafaxine, duloxetine).

• Antiepileptic medications include gabapentin, valproate, lamotrigine, carbamazepine, oxcarbazepine, phenytoin and lacrosamide.

• Opiate or opiate-derivative agents include oxycodone, morphine sulfate, hydromorphone, fentanyl and tramadol.

• Other agents include topical agents (lidocaine cream, lidoderm patches, capsaicin cream), neutriceuticals (Metanx, alpha-lipoic acid) and devices (spinal stimulators, transcutaneous electrical nerve stimulation).