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- Endocrine pancreatic insufficiency occurring after surgical resection of the pancreas
- Includes the development of new-onset diabetes, exacerbation of pre-existing diabetes, or progression of pre-existing glucose intolerance to overt diabetes
- Important factors include: amount of pancreatic parenchymal tissue removed, resection vs "sparing" of adjacent organs, preoperative pancreatic function, peripheral insulin resistance, preoperative diabetes, and postoperative changes in nutrition.