Diabetic Kidney Disease

Daphne H. Knicely, M.D., Donna Myers, M.D.
Diabetic Kidney Disease is a topic covered in the Johns Hopkins Diabetes Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

DEFINITION

  • Diabetic kidney disease (DKD) is one of the common long-term, microvascular complications of diabetes.
  • DKD remains the most common cause of end-stage renal disease (ESRD) in Western societies, accounting for 45% of ESRD cases.[64]
  • Characterized initially by moderately increased albuminuria, formerly called "microalbuminuria" (30-300 mg albumin/g creatinine); then severely increased albuminuria, formerly called "macroalbuminuria" (>300 mg albumin/g creatinine); followed by renal insufficiency as evidenced by elevated BUN and creatinine; and finally ESRD.[1][2]
  • Histologic findings in DKD includes basement membrane thickening, mesangial expansion, nodular glomerulosclerosis with classic Kimmelstein-Wilson nodules (late finding), specific vascular lesions including arterial hyalinosis, and tubulointerstitial changes such as development of fibrosis. Ultimately, this results in progressive albuminuria, reduction in glomerular filtration rate (GFR), elevation of arterial blood pressure and fluid retention.[12][9]

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: November 5, 2015

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Diabetic Kidney Disease ID - 547097 A1 - Knicely,Daphne,M.D. AU - Myers,Donna,M.D. Y1 - 2015/11/05/ PB - Johns Hopkins Diabetes Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547097/all/Diabetic_Kidney_Disease ER -