Mitochondrial diabetes

David Cooke, M.D., Yasmin Akhtar, DO, MPH, Ali Mohamadi, M.D.


  • Mutations in the mitochondrial genome (mtDNA) can cause diabetes mellitus (DM).
  • The distinguishing clinical feature of mitochondrial diabetes is in association with other symptoms, including hearing impairment, neurological disorders, cardiac failure, and renal failure.
  • These mutations can be large deletions, duplications, rearrangements, or point mutations.

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Last updated: April 2, 2019