Johns Hopkins Diabetes GuideManagementSpecific Populations or Subtypes

Mitochondrial diabetes

David Cooke, M.D., Ali Mohamadi, M.D.
Mitochondrial diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

  • Mutations in the mitochondrial genome (mtDNA) can cause diabetes mellitus (DM).
  • The distinguishing clinical feature of mitochondrial diabetes is association with other symptoms, including hearing impairment, neurological disorders, cardiac failure, and renal failure.
  • These mutations can be large deletions, duplications, rearrangements, or point mutations.

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Last updated: October 6, 2015