Johns Hopkins Diabetes GuideComplications and ComorbiditiesEndocrine

Glucagonoma

Nestoras Mathioudakis, M.D., MHS, Douglas Ball, M.D.
Glucagonoma is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

  • A rare tumor originating from the alpha cells of the pancreas that results in hypersecretion of glucagon.
  • Mild diabetes mellitus is a classic presenting feature of glucagonoma.
  • Hyperglycemia results from the glycogenolytic and gluconeogenic effects of glucagon and low insulin-to-glucagon ratio.

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Last updated: December 17, 2015