Fibric Acid Derivatives

Alona Crowder, PharmD, Simeon Margolis, M.D.
Fibric Acid Derivatives is a topic covered in the Johns Hopkins Diabetes Guide.

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INDICATIONS

FDA

  • Primary hypercholesterolemia or mixed dyslipidemia: To reduce LDL, total cholesterol, and triglycerides.
    • Of note, this class of medications has not shown a reduction in coronary heart disease morbidity and mortality in large, randomized controlled trials of patients with type 2 diabetes mellitus.[1][2]
  • Hypertriglyceridemia: Adjunct to diet treatment and improved glycemic control in patients with diabetes.

NON-FDA APPROVED USES

  • Prevention of acute pancreatitis secondary to severe hypertriglyceridemia

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INDICATIONS

FDA

  • Primary hypercholesterolemia or mixed dyslipidemia: To reduce LDL, total cholesterol, and triglycerides.
    • Of note, this class of medications has not shown a reduction in coronary heart disease morbidity and mortality in large, randomized controlled trials of patients with type 2 diabetes mellitus.[1][2]
  • Hypertriglyceridemia: Adjunct to diet treatment and improved glycemic control in patients with diabetes.

NON-FDA APPROVED USES

  • Prevention of acute pancreatitis secondary to severe hypertriglyceridemia

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Last updated: January 7, 2018