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Diuretic Class Review
Pregnancy Risk Category/ Breastfeeding Risk
Cost and Formulation
Treatment of mild to moderate HTN; treatment of edema in heart failure and nephrotic syndrome
Management of mild to moderate HTN; adjunct treatment for edema
Category C, but most experts do not recommend.
Generic tablets available. Oral suspension still brand.
Management of mild-to-moderate hypertension; treatment of edema in heart failure and nephrotic syndrome, impaired renal function
Management of edema associated with excessive aldosterone excretion; hypertension; primary hyperaldosteronism; hypokalemia; cirrhosis of liver accompanied by edema or ascites; nephritic syndrome; severe heart failure (NYHA class III-IV) to increase survival and reduce hospitalization when added to standard therapy
Category C (teratogenic in animal studies)
Alone or in combination with other diuretics in treatment of edema and hypertension; decreases potassium excretion caused by kaliuretic diuretics
No generic available.
Management of edema associated with heart failure and hepatic or renal disease; acute pulmonary edema; treatment of hypertension (alone or in combination with other antihypertensives)
Generic available, in both tablet and solution form.
Management of edema secondary to heart failure or hepatic or renal disease including nephritic disease; may be used alone or in combination with antihypertensives for treatment of HTN; can be used in furosemide allergic patients.
A: 85-95% absorbed
Category C (per manufacturer); D (per expert analysis)
**Patient Assistant Program:
** Information gathered by Heather Tran and Gladimir Elysee
A = absorption; M = metabolism; E = excretion