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Cancer and Diabetes
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- Diabetes associated with increased risk of non-Hodgkin lymphoma and cancer of breast, colorectum, endometrium, liver, and pancreas.
- Negatively associated with risk of prostate cancer.
- Hypotheses about possible link between diabetes and cancer include:
Diabetes and cancer death
- Diabetes associated with:
- Also reported positive associations with death from:
- esophagus, liver, and colon/rectum cancers in men, and
- liver and cervix cancers in women
Diabetes in Cancer Patients
- Meta-analyses showed diabetes associated with an increased mortality in patients with any cancer [HR of 1.44], cancers of the endometrium (HR, 1.76), breast (HR, 1.61), colorectum (HR, 1.32), and prostate.
- Meta-analysis showed diabetes associated with increased odds of postoperative mortality across all cancer types [HR=1.5].
- Hyperglycemia associated with shorter duration of complete remission in patients with acute lymphocytic leukemia.
- Hyperglycemia associated with shorter survival in patients with newly diagnosed glioblastoma.
Diabetes and Prostate Cancer
Obesity and Cancer
- A meta-analysis showed BMI strongly associated with:
- oesophageal adenocarcinoma (RR 1.52), thyroid (RR 1.33), colon (RR 1.24), and renal (RR 1.24) cancers. (all p< 0.001 )
- endometrial (RR 1.59), gallbladder (RR 1.59), esophageal (RR 1.51), and renal (RR 1.34) cancers in women. (all p< 0.05)
- weaker positive associations with cancer and malignant melanoma in men
- Patients with gastric bypass surgery had a lower risk of cancer incidence and mortality compared to severely obese patients