Cancer and Diabetes
EPIDEMIOLOGY
Incident Cancer:
Incident Cancer:
Diabetes and cancer death
Diabetes and cancer death
- Diabetes associated with:
- Increased risk of death from colon and pancreatic cancer in both men and women;
- Increased risk of death from liver and bladder cancers in men; and
- Increased risk of death from breast cancer in women[54]
- Also reported positive associations with death from:
- Esophagus, liver, and colon/rectum cancers in men, and
- Liver and cervix cancers in women[52]
Diabetes in Cancer Patients
Diabetes in Cancer Patients
- Meta-analyses showed diabetes associated with an increased mortality in patients with any cancer [HR of 1.44], cancers of the endometrium (HR, 1.76), breast (HR, 1.61), colorectum (HR, 1.32), and prostate[28][24].
- Meta-analysis showed diabetes associated with increased odds of postoperative mortality across all cancer types [HR=1.5][28].
- Hyperglycemia associated with shorter duration of complete remission in patients with acute lymphocytic leukemia[53].
- Hyperglycemia associated with shorter survival in patients with newly diagnosed glioblastoma[32].
Diabetes and Prostate Cancer
Diabetes and Prostate Cancer
Obesity and Cancer
Obesity and Cancer
- Relative risks from meta-analyses or pooled analyses range from 1.2 to 1.5 for overweight and 1.5 to 1.8 for obesity with respect to cancers of the colon[39], gastric cardia[11], liver[13], gallbladder[56], pancreas[21], and kidney[5]. The relative risk for esophageal adenocarcinoma is even higher, up to 4 fold in those who are extremely obese.
- The International Agency for Research on Cancer (IARC) has concluded that excess body weight increases risk for many types of cancer[2]: esophagus, colon, rectum, kidney, pancreas, uterus, ovary, post-menopausal breast, stomach cardia, liver, gallbladder, meningioma, thyroid, and multiple myeloma.
- Patients with gastric bypass surgery had a lower risk of cancer incidence and mortality compared to severely obese patients[43][34].
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Last updated: March 3, 2019
Citation
Yeh, Hsin-Chieh. "Cancer and Diabetes." Johns Hopkins Diabetes Guide, 2019. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547023/all/Cancer_and_Diabetes.
Yeh H. Cancer and Diabetes. Johns Hopkins Diabetes Guide. 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547023/all/Cancer_and_Diabetes. Accessed September 27, 2023.
Yeh, H. (2019). Cancer and Diabetes. In Johns Hopkins Diabetes Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547023/all/Cancer_and_Diabetes
Yeh H. Cancer and Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2019. [cited 2023 September 27]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547023/all/Cancer_and_Diabetes.
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