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- Diabetic autonomic neuropathy (DAN) is a common, under appreciated complication of diabetes with significant negative impact on survival and quality of life.
- Involvement of autonomic nerves in diabetes follows a length-dependent pattern. The longest autonomic nerve - the vegus nerve - is the first affected, and provides 75% of parasympathetic tone, with a broad range of effects.
- Later, loss of sympathetic nerve function can also occur.