Autoantibodies in Type 1 Diabetes
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4 autoantibodies are markers of beta cell autoimmunity in type 1 diabetes: Islet Cell Antibodies (ICA, against cytoplasmic proteins in the beta cell), antibodies to Glutamic Acid Decarboxylase (GAD-65), Insulin Autoantibodies (IAA), and IA-2A, to protein tyrosine
Autoantibodies against GAD 65 are found in 80% of type 1 diabetics at clinical presentation
Presence of ICA and IA-2A at diagnosis for type 1 diabetes range from 69-90% and 54-75%, respectively
IAA prevalence correlates inversely with age at onset of diabetes; it is usually the first marker in young children at risk for diabetes
and found in approximately 70% of young children at time of diagnosis
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Last updated: October 6, 2015
Donner, Thomas, et al. "Autoantibodies in Type 1 Diabetes." Johns Hopkins Diabetes Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes.
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes. Johns Hopkins Diabetes Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes. Accessed September 21, 2019.
Donner, T., Champaneri, S., & Saudek, C. (2015). Autoantibodies in Type 1 Diabetes. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes
Donner T, Champaneri S, Saudek C. Autoantibodies in Type 1 Diabetes [Internet]. In: Johns Hopkins Diabetes Guide. ; 2015. [cited 2019 September 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547013/all/Autoantibodies_in_Type_1_Diabetes.
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T1 - Autoantibodies in Type 1 Diabetes
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A1 - Donner,Thomas,M.D.
AU - Champaneri,Shivam,M.D.
AU - Saudek,Christopher,M.D.
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