Johns Hopkins Diabetes GuideMedicationsGlucose-Raising

Antimicrobials with Special Precautions in Diabetes

Antimicrobials with Special Precautions in Diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

DEFINITION

  • Certain antibiotics may produce undesired changes in glycemic control when used in persons with diabetes.
  • No apparent interactions are described between antibiotics and insulins.
  • Serum concentrations of hypoglycemic agents may change due to inhibition or induction of oxidative metabolism (i.e. cytochrome P450 system) including: meglitinides (repaglinide, nateglinide), sulfonylureas (glyburide, glimepiride, glipizide), and glitizones (pioglitazone, rosiglitazone).
  • Specific cytochrome P450 substrates: repaglinide (2C8, 3A4); nateglinide (2C9>3A4); glyburide and glipizide (2C9); pioglitazone (3A4>2C8); rosiglitazone (2C8> 2C9).
  • Limited number of potential drug-drug interactions observed with metformin.

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: January 5, 2017