Johns Hopkins Diabetes GuideBrand Names

Anticoagulant Use (Aspirin, Clopidogrel, Warfarin)

Sheldon H. Gottlieb, M.D., Paul A. Pham, Pharm.D.
Anticoagulant Use (Aspirin, Clopidogrel, Warfarin) is a topic covered in the Johns Hopkins Diabetes Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

INDICATIONS

FDA

  • Aspirin: secondary prevention: treatment of transient transchemic attack (TIA) and ischemic stroke; prevent recurrent myocardial infarction (MI); reduce risk of MI or sudden death in unstable angina and chronic stable angina; after angioplasty, coronary artery bypass graft (CABG), carotid endarterectomy.
  • Clopidogrel (Plavix): secondary prevention: acute coronary syndromes (unstable angina, non-ST elevation MI including those who are to be managed with coronary revascularization, ST elevation MI, after MI, stroke, established peripheral vascular disease.
  • Warfarin: secondary indication: prophylaxis or treatment of thromboembolism in atrial fibrillation, mechanical heart valves; reduce risk of stroke or recurrent MI after MI; prophylaxis or treatment of venous thrombosis or thromboembolism in high-risk patients.
  • Dabigatran (Pradaxa): primary and secondary prevention of stroke in non-valvular atrial fibrillation. FDA warning: do not use in patients with mechanical heart valves.
  • Rivaroxaban (Xarelto): primary and secondary prevention of sroke in non-valvular atrial fibrillation; prevention of deep vein thrombosis (DVT) after hip and knee surgery; secondary prevention after DVT and pulmonary embolism.
  • Apixaban (Eliquis): primary and secondary prevention of stroke in non-valvular atrial fibrillation.

NON-FDA APPROVED USES

  • Aspirin: primary prevention of cardiovascular events in diabetes (see Routine Preventive Care).
  • Clopidogrel (Plavix): primary prevention not established.
  • Warfarin: primary prevention not established.
  • Pradaxa, Rivaroxaban, Apixaban: primary prevention not established. Note FDA warnings re: mechanical heart valves.

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: September 27, 2013