is a topic covered in the Johns Hopkins Diabetes Guide
To view the entire topic, please sign in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
- A clinical syndrome resulting from excessive secretion of growth hormone (GH).
- GH excess prior to closure of the epiphyseal plates results in gigantism; after epiphyseal plate closure, the result is acromegaly.
- Somatic and metabolic effects of chronic GH hypersecretion are predominantly mediated by high levels of insulin-like growth factor-1 (IGF-1).
- Acromegaly is an uncommon secondary cause of diabetes.
- Excess GH: 1) stimulates gluconeogenesis and lipolysis, causing hyperglycemia and elevated free fatty acid levels; 2) leads to both hepatic and peripheral insulin resistance, with compensatory hyperinsulinemia. Conversely, IGF-1 increases insulin sensitivity. However, in acromegaly, increased IGF-1 levels are unable to overcome the insulin-resistant state caused by GH excess.
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
Last updated: June 14, 2011
Ball, Douglas. "Acromegaly." Johns Hopkins Diabetes Guide, 2011. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly.
Ball D. Acromegaly. Johns Hopkins Diabetes Guide. 2011. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly. Accessed May 20, 2019.
Ball, D. (2011). Acromegaly. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly
Ball D. Acromegaly [Internet]. In: Johns Hopkins Diabetes Guide. ; 2011. [cited 2019 May 20]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly.
TY - ELEC
T1 - Acromegaly
ID - 547003
A1 - Ball,Douglas,M.D.
Y1 - 2011/06/14/
BT - Johns Hopkins Diabetes Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly
DB - Johns Hopkins Guide
DP - Unbound Medicine