Tags

Type your tag names separated by a space and hit enter

Acromegaly

Douglas Ball, M.D.
Acromegaly is a topic covered in the Johns Hopkins Diabetes Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

DEFINITION

  • A clinical syndrome resulting from excessive secretion of growth hormone (GH).
  • GH excess prior to closure of the epiphyseal plates results in gigantism; after epiphyseal plate closure, the result is acromegaly.
  • Somatic and metabolic effects of chronic GH hypersecretion are predominantly mediated by high levels of insulin-like growth factor-1 (IGF-1).
  • Acromegaly is an uncommon secondary cause of diabetes.
  • Excess GH: 1) stimulates gluconeogenesis and lipolysis, causing hyperglycemia and elevated free fatty acid levels; 2) leads to both hepatic and peripheral insulin resistance, with compensatory hyperinsulinemia. Conversely, IGF-1 increases insulin sensitivity. However, in acromegaly, increased IGF-1 levels are unable to overcome the insulin-resistant state caused by GH excess.

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: June 2, 2019

Citation

Ball, Douglas. "Acromegaly." Johns Hopkins Diabetes Guide, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly.
Ball D. Acromegaly. Johns Hopkins Diabetes Guide. 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly. Accessed July 22, 2019.
Ball, D. (2019). Acromegaly. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly
Ball D. Acromegaly [Internet]. In: Johns Hopkins Diabetes Guide. ; 2019. [cited 2019 July 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Acromegaly ID - 547003 A1 - Ball,Douglas,M.D. Y1 - 2019/06/02/ BT - Johns Hopkins Diabetes Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547003/all/Acromegaly DB - Johns Hopkins Guide DP - Unbound Medicine ER -