Johns Hopkins ABX Guide
Brincidofovir
INDICATIONS
FDA
FDA
- Treatment of human smallpox disease in adults and pediatric patients, including neonates
- Approved by the FDA in June 2021 for the treatment of smallpox through the FDA Animal Rule.
- Effectiveness not determined in humans.
- Efficacy may be reduced in immunocompromised patients (based on animal data in immunodeficient animals).
- Approved by the FDA in June 2021 for the treatment of smallpox through the FDA Animal Rule.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Chimerix transferred exclusive rights for mpox therapy to Emergent BioSolutions in 2022.
- The development of brincidofovir for other indications (e.g., adenovirus) was transferred to SymBio Pharmaceuticals Ltd in 2019.
- Inquire with SymBio about non-mpox uses of brincidofovir.
- Mpox: used usually in combination for serious infection in patients who are severely immunosuppressed.
- Brincidofovir may be obtained by a clinician’s request to the FDA through an emergency expanded access program or an emergency IND.
- The development of brincidofovir for other indications (e.g., adenovirus) was transferred to SymBio Pharmaceuticals Ltd in 2019.
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Last updated: April 10, 2026
Citation
Auwaerter, Paul G, and Kathryn Dzintars. "Brincidofovir." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540772/12/Brincidofovir.
Auwaerter PG, Dzintars K. Brincidofovir. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540772/12/Brincidofovir. Accessed April 21, 2026.
Auwaerter, P. G., & Dzintars, K. (2026). Brincidofovir. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540772/12/Brincidofovir
Auwaerter PG, Dzintars K. Brincidofovir [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 April 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540772/12/Brincidofovir.
* Article titles in AMA citation format should be in sentence-case
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PB - The Johns Hopkins University
DB - Johns Hopkins Guides
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