Johns Hopkins ABX Guide
Baricitinib
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INDICATIONS
FDA
The FDA issued an Emergency Use Authorization (EUA) permitting the use of baricitinib, in combination with remdesivir, for treatment of suspected or laboratory-confirmed COVID-19 disease in hospitalized adults and pediatric patients (> 2 years of age) requiring supplemental oxygen, invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO).
Patient Selection
- Evaluate baseline eGFR, liver enzymes, and complete blood count to determine treatment suitability. Monitor patients with abnormal baseline values closely.
- Baricitinib is not recommended for:
- Patients with ESRD, or those receiving dialysis
- Patients with known active tuberculosis
- Limited information is available on the use of baricitinib in combination with systemic corticosteroids for the management of patients with COVID-19.
To request baricitinib under the EUA, inpatient pharmacies may order directly from an Authorized Distributor or Record. See www.baricitinibemergencyuse.com for additional information.
> Baricitinib is FDA approved in adult patients for the management of moderate to severe active rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF)-antagonist therapies. No additional information related to this treatment indication will be included in the rest of the drug summary.
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INDICATIONS
FDA
The FDA issued an Emergency Use Authorization (EUA) permitting the use of baricitinib, in combination with remdesivir, for treatment of suspected or laboratory-confirmed COVID-19 disease in hospitalized adults and pediatric patients (> 2 years of age) requiring supplemental oxygen, invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO).
Patient Selection
- Evaluate baseline eGFR, liver enzymes, and complete blood count to determine treatment suitability. Monitor patients with abnormal baseline values closely.
- Baricitinib is not recommended for:
- Patients with ESRD, or those receiving dialysis
- Patients with known active tuberculosis
- Limited information is available on the use of baricitinib in combination with systemic corticosteroids for the management of patients with COVID-19.
To request baricitinib under the EUA, inpatient pharmacies may order directly from an Authorized Distributor or Record. See www.baricitinibemergencyuse.com for additional information.
> Baricitinib is FDA approved in adult patients for the management of moderate to severe active rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF)-antagonist therapies. No additional information related to this treatment indication will be included in the rest of the drug summary.
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