Johns Hopkins ABX Guide
Imipenem/cilastatin/relebactam
INDICATIONS
FDA
FDA
- Treatment of the following infections caused by susceptible Gram-negative bacteria in adults and pediatric patients weighing ≥ 2 kg:
- Hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP)
- Treatment of complicated urinary tract infections, including pyelonephritis (cUTI*) in patients who have limited or no alternative treatment options.
- Complicated intra-abdominal infections (cIAI*) in patients who have limited or no alternative treatment options.
*Approval of the cUTI and cIAI indications is based on limited clinical safety and efficacy data.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of susceptible KPC-producing Enterobacterales (KPC-E) and DTR P. aeruginosa infections outside FDA-approved indications (e.g., bacteremia, osteomyelitis).
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Last updated: September 6, 2026
Citation
Soto, Caitlin, and Edina Avdic. "Imipenem/cilastatin/relebactam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540727/all/Imipenem_cilastatin_relebactam.
Soto C, Avdic E. Imipenem/cilastatin/relebactam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540727/all/Imipenem_cilastatin_relebactam. Accessed September 15, 2026.
Soto, C., & Avdic, E. (2026). Imipenem/cilastatin/relebactam. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540727/all/Imipenem_cilastatin_relebactam
Soto C, Avdic E. Imipenem/cilastatin/relebactam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 September 15]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540727/all/Imipenem_cilastatin_relebactam.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Imipenem/cilastatin/relebactam
ID - 540727
A1 - Soto,Caitlin,PharmD, BCIDP
AU - Avdic,Edina,Pharm.D.
Y1 - 2026/09/06/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540727/all/Imipenem_cilastatin_relebactam
PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
ER -
