Pretomanid

Edina Avdic, Pharm.D.
Pediatric Dosing Author: Lisa Hutchins, Pharm.D.
Pretomanid is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Treatment of adults with pulmonary extensively drug-resistant (XDR) TB and treatment-intolerant or nonresponsive multidrug-resistant (MDR) TB in a combination regimen with bedaquiline and linezolid.
    • Limitations of Use: Pretomanid is not indicated for patients with drug-sensitive TB, latent TB, extra-pulmonary infection due to M. tuberculosis, MDR-TB that is not treatment-intolerant or nonresponsive to standard therapy
    • Safety and effectiveness have not been established in combination with drugs other than bedaquiline and linezolid.

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INDICATIONS

FDA

  • Treatment of adults with pulmonary extensively drug-resistant (XDR) TB and treatment-intolerant or nonresponsive multidrug-resistant (MDR) TB in a combination regimen with bedaquiline and linezolid.
    • Limitations of Use: Pretomanid is not indicated for patients with drug-sensitive TB, latent TB, extra-pulmonary infection due to M. tuberculosis, MDR-TB that is not treatment-intolerant or nonresponsive to standard therapy
    • Safety and effectiveness have not been established in combination with drugs other than bedaquiline and linezolid.

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Last updated: February 10, 2020