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    Bedaquiline

    Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D. BCPS
    Bedaquiline is a topic covered in the Johns Hopkins ABX Guide.

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    INDICATIONS

    FDA

    • Treatment of pulmonary MDR TB (resistant to at least INH and rifampin) in combination with other active antimycobacterial agents (minimum of four-drug treatment regimen) when an effective treatment regimen cannot otherwise be provided.
    • Limitation of use: the safety and efficacy of bedaquiline for the treatment of latent infection due to Mycobacterium tuberculosis or drug-sensitive TB has not been established.
      • In addition, there are limited data on the treatment of extra-pulmonary TB (e.g., central nervous system).

    NON-FDA APPROVED USES

    • On a case-by-case basis bedaquiline can be considered in extra-pulmonary TB, children, pregnant women, and HIV-infected patients when an effective anti-TB cannot be provided otherwise (CDC recommendation)
    • Treatment of MAC and M. abscessus when there are no other alternatives

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    Last updated: January 2, 2019

    Citation

    Avdic, Edina, and Paul A Pham. "Bedaquiline." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline.
    Avdic E, Pham PA. Bedaquiline. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline. Accessed March 23, 2019.
    Avdic, E., & Pham, P. A. (2019). Bedaquiline. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline
    Avdic E, Pham PA. Bedaquiline [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 March 23]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Bedaquiline ID - 540629 A1 - Avdic,Edina,Pharm.D. AU - Pham,Paul,Pharm.D. BCPS Y1 - 2019/01/02/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -