Johns Hopkins ABX Guide
Bedaquiline
INDICATIONS
FDA
FDA
- Treatment of pulmonary MDR TB (resistant to at least INH and rifampin) in combination with other active antimycobacterial agents (minimum of four-drug treatment regimen) when an effective treatment regimen cannot otherwise be provided.
- Limitation of use: the safety and efficacy of bedaquiline for the treatment of latent infection due to Mycobacterium tuberculosis or drug-sensitive TB has not been established.
- In addition, there are limited data on the treatment of extra-pulmonary TB (e.g., central nervous system).
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- On a case-by-case basis bedaquiline can be considered in extra-pulmonary TB, children, pregnant women, and HIV-infected patients when an effective anti-TB cannot be provided otherwise (CDC recommendation)
- Treatment of MAC and M. abscessus when there are no other alternatives
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Last updated: January 2, 2019
Citation
Avdic, Edina, and Paul A Pham. "Bedaquiline." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline.
Avdic E, Pham PA. Bedaquiline. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline. Accessed September 28, 2023.
Avdic, E., & Pham, P. A. (2019). Bedaquiline. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline
Avdic E, Pham PA. Bedaquiline [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2023 September 28]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540629/all/Bedaquiline.
* Article titles in AMA citation format should be in sentence-case
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BT - Johns Hopkins ABX Guide
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PB - The Johns Hopkins University
DB - Johns Hopkins Guides
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