BK Virus
BK Virus is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- DNA polyomavirus, first isolated in 1971 from the urine of a renal transplant patient with ureteral stenosis whose initials were B.K.
- Other members of the polyomavirus family:
- JC virus, ~75% information shared genomically, KI polyomavirus, WU polyomavirus and trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus.
- Important viral components are large tumor antigen (T antigen), small tumor antigen (t antigen) and capsid proteins (VP1, VP2, VP3 and agnoprotein)
- Subtypes: Subtype 1 is the most common, followed by subtype 4. Subtypes 3 and 4 are much less common. Serostatus of donor and recipient may impact risk for viral reactivation in kidney transplant.
- PCR is best suited for detecting subtype 1. Some subtype 3 and 4 isolates have polymorphisms that may impact their detection, leading to falsely low viral load measurements
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MICROBIOLOGY
- DNA polyomavirus, first isolated in 1971 from the urine of a renal transplant patient with ureteral stenosis whose initials were B.K.
- Other members of the polyomavirus family:
- JC virus, ~75% information shared genomically, KI polyomavirus, WU polyomavirus and trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus.
- Important viral components are large tumor antigen (T antigen), small tumor antigen (t antigen) and capsid proteins (VP1, VP2, VP3 and agnoprotein)
- Subtypes: Subtype 1 is the most common, followed by subtype 4. Subtypes 3 and 4 are much less common. Serostatus of donor and recipient may impact risk for viral reactivation in kidney transplant.
- PCR is best suited for detecting subtype 1. Some subtype 3 and 4 isolates have polymorphisms that may impact their detection, leading to falsely low viral load measurements
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Last updated: January 14, 2023
Citation
Shoham, Shmuel. "BK Virus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540620/all/BK_Virus.
Shoham S. BK Virus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540620/all/BK_Virus. Accessed January 27, 2023.
Shoham, S. (2023). BK Virus. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540620/all/BK_Virus
Shoham S. BK Virus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2023 January 27]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540620/all/BK_Virus.
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