Johns Hopkins ABX Guide
Anaplasma phagocytophilum
MICROBIOLOGY
- Cause of tick-borne infection in humans.
- Human granulocytic anaplasmosis (HGA), formerly known as human granulocytic ehrlichiosis (HGE).
- The organism is currently known as Anaplasma phagocytophilum, transmitted by Ixodes scapularis (black-legged deer tick) on the Eastern Seaboard and in New England, the Mid-Atlantic, and the Upper Midwest; and on the West Coast by the western black-legged tick (Ixodes pacificus)—the same vectors as for Lyme disease (Borrelia burgdorferi).
- Anaplasma marginale infects cattle.
- An obligate, intracellular pathogen that tends to multiply in granulocytes within vacuoles that may form morulae.
- See Ehrlichia spp. module for disease (human monocytic ehrlichiosis [HME] and others) caused by similar tick-borne pathogens.
- Occasionally seen as a Gram-negative organism upon staining.
- The organism is currently known as Anaplasma phagocytophilum, transmitted by Ixodes scapularis (black-legged deer tick) on the Eastern Seaboard and in New England, the Mid-Atlantic, and the Upper Midwest; and on the West Coast by the western black-legged tick (Ixodes pacificus)—the same vectors as for Lyme disease (Borrelia burgdorferi).
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Last updated: December 11, 2022
Citation
Auwaerter, Paul G. "Anaplasma Phagocytophilum." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum.
Auwaerter PG. Anaplasma phagocytophilum. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum. Accessed September 22, 2023.
Auwaerter, P. G. (2022). Anaplasma phagocytophilum. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum
Auwaerter PG. Anaplasma Phagocytophilum [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2023 September 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum.
* Article titles in AMA citation format should be in sentence-case
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