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Vibrio cholerae is a topic covered in the Johns Hopkins ABX Guide.

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  • Aerobic, Gram-negative, comma-shaped bacillus.
    • Cary Blair media suggested for transport.
    • Selective thiosulfate–citrate–bile salts agar (TCBS) best used for culture.
  • Water-borne pathogen, humans usually acquire infection through ingesting contaminated water or food. Countries may have endemic infection (ongoing continuously often with spikes during rainy season) or epidemics.
    • V. cholerae serogroup O1, biotype El Tor, originated in Asia but has caused infection (seventh cholera pandemic) throughout Africa and South America for ~43 yrs.
    • Newer serogroup, O139 described in SE Asia in 1992 now endemic.
  • Isolates described with resistance to ampicillin, tetracycline, ampicillin, aminoglycosides, sulfonamides, fluoroquinolones and trimethoprim.
  • Non-01 V. cholerae strains (also water-borne, may be non-toxigenic) can rarely cause non-diarrheal illness such as bacteremia and wound infections especially in cirrhotics. Infections may be from fresh or brackish waters.

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Last updated: January 3, 2018


Auwaerter, Paul G. "Vibrio Cholerae." Johns Hopkins ABX Guide, The Johns Hopkins University, 2018. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540585/all/Vibrio_cholerae.
Auwaerter PG. Vibrio cholerae. Johns Hopkins ABX Guide. The Johns Hopkins University; 2018. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540585/all/Vibrio_cholerae. Accessed July 24, 2019.
Auwaerter, P. G. (2018). Vibrio cholerae. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540585/all/Vibrio_cholerae
Auwaerter PG. Vibrio Cholerae [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2018. [cited 2019 July 24]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540585/all/Vibrio_cholerae.
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