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Tigecycline

Kathryn Dzintars, Pharm.D., BCPS
Tigecycline is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Complicated skin and skin structure infections (including those caused by MRSA and vancomycin-susceptible E. faecalis).
    • Author’s comment: avoid in severe infections +/- bacteremia.
  • Complicated intra-abdominal infections (as a single agent).
    • Author’s comment: avoid in severe infections +/- bacteremia.
  • Community-acquired bacterial pneumonia caused by S. pneumoniae (PCN-susceptible isolates), H. influenzae (beta-lactamase negative isolates), and Legionella pneumophila.
    • Author’s comment: not a first-line agent and generally not used for CAP.

NON-FDA APPROVED USES

  • HAP/VAP due to MDR GNR, but high rates of clinical failure reported[5].
    • In critically ill patients, consider using tigecycline in combination with carbapenem or colistin.

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Last updated: December 4, 2018

Citation

Dzintars, Kathryn. "Tigecycline." Johns Hopkins ABX Guide, The Johns Hopkins University, 2018. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540549/all/Tigecycline.
Dzintars K. Tigecycline. Johns Hopkins ABX Guide. The Johns Hopkins University; 2018. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540549/all/Tigecycline. Accessed May 24, 2019.
Dzintars, K. (2018). Tigecycline. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540549/all/Tigecycline
Dzintars K. Tigecycline [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2018. [cited 2019 May 24]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540549/all/Tigecycline.
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TY - ELEC T1 - Tigecycline ID - 540549 A1 - Dzintars,Kathryn,Pharm.D., BCPS Y1 - 2018/12/04/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540549/all/Tigecycline PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -