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- Alternative in PCN-allergic patients: syphilis, yaws, Vincent’s infections and infections caused by N. gonorrhoeae (no longer recommended), B. anthracis, L. monocytogenes, Actinomyces spp., and Clostridium spp.
- URI and lower respiratory tract infections
- Skin and soft tissue infections
- Granuloma inguinale
- Psittacosis caused by Chlamydia psittaci.
- Typhus infections, Rocky Mountain spotted fever, rickettsial infections
- Q fever
- Infections caused by Chlamydia trachomatis
- Urinary tract infections
- Infections caused by Borrelia spp.
- Bartonella bacilliformis
- H. ducreyi
- F. tularensis
- Y. pestis
- V. cholerae
- Brucella spp.
- Campylobacter fetus
- Adjunctive to intestinal amebiasis cause by E. histolytica
- Infections caused by susceptible strains of E. coli, Enterobacter aerogenes, Shigella sp., Acinetobacter sp. Klebsiella sp., Bacteroides sp.