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Streptococcus pyogenes (Group A)

Streptococcus pyogenes (Group A) is a topic covered in the Johns Hopkins ABX Guide.

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  • Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar. See Streptococcal species or S. pneumoniae modules for other streptococci.
    • Streptococcus pyogenes, Lancefield group A.
    • Gram-positive cocci in chains [Fig 1].
  • Ecologic niches are pharynx, genital mucosa and skin; colonization rates:
    • Adults 2-3%
    • School children 15-20%
  • Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
    • M protein gene (emm) ~100 serotypes
      • May be used to track outbreaks, public health tracking of invasive infections
      • Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.

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Last updated: August 9, 2019


Auwaerter, Paul G, and John G Bartlett. "Streptococcus Pyogenes (Group A)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
Auwaerter PG, Bartlett JG. Streptococcus pyogenes (Group A). Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_. Accessed August 21, 2019.
Auwaerter, P. G., & Bartlett, J. G. (2019). Streptococcus pyogenes (Group A). In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_
Auwaerter PG, Bartlett JG. Streptococcus Pyogenes (Group A) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 August 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
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TY - ELEC T1 - Streptococcus pyogenes (Group A) ID - 540524 A1 - Auwaerter,Paul,M.D. AU - Bartlett,John,M.D. Y1 - 2019/08/09/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_ PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -