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Streptococcus pyogenes (Group A)

Streptococcus pyogenes (Group A) is a topic covered in the Johns Hopkins ABX Guide.

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  • Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar.
    • Streptococcus pyogenes, Lancefield group A.
    • Gram-positive cocci in chains.
  • Ecologic niche is pharynx, colonization rates:
    • Adults 2-3%
    • School children 15-20%
  • Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
    • M protein gene (emm) ~100 serotypes
      • May be used to track outbreaks, public health tracking of invasive infections
      • Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.
  • See Streptococcus species module for non-GAS strep organisms or S. pneumoniae.

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Last updated: November 8, 2016


Bartlett, John G. "Streptococcus Pyogenes (Group A)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
Bartlett JG. Streptococcus pyogenes (Group A). Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_. Accessed March 22, 2019.
Bartlett, J. G. (2016). Streptococcus pyogenes (Group A). In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_
Bartlett JG. Streptococcus Pyogenes (Group A) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 March 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
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TY - ELEC T1 - Streptococcus pyogenes (Group A) ID - 540524 A1 - Bartlett,John,M.D. Y1 - 2016/11/08/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_ PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -