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- Polymicrobial in up to 25% including anaerobes.
- Gram-negative bacilli, especially
- Staphylococcus aureus
- Candida spp.
- Neutropenia and chronic corticosteroid use predispose to candidal splenic abscesses.
- Chronic disseminated candidiasis (formerly hepatosplenic candidiasis) often include frank candidal splenic abscesses.