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- Gram negative bacilli, especially E. coli and Salmonella spp.
- Staphylococcus aureus
- Streptococci and enterococci
- Candida spp.
- Neutropenia and chronic corticosteroid use predispose to candida splenic abscesses.
- Chronic disseminated candidiasis (formerly hepatosplenic candidiasis) often include frank candidal splenic abscesses.
- Rarely, Brucella spp.
- Polymicrobial in up to 25% including anaerobes.
- Given that most splenic abscesses are secondary to bacteremia or fungemia (e.g., associated with endocarditis , UTI , pancreatitis, GI tract, etc.), the likely pathogen(s) are determined by original focus.