Shigella species

Paul G. Auwaerter, M.D.
Shigella species is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Aerobic Gram-negative rod (Fig), non-motile, non-spore-forming), family Enterobacteriaceae.
  • Four groups: subdivided into serotypes and subserotypes based upon lipopolysaccharide O antigenic repeats.
    • Group A (S. dysenteriae, see separate module for discussion of Group A infections, often cause of pandemics arising from natural and man-made disasters)
    • Group B (S. flexneri, leading cause in low- and middle-income countries)
    • Group C (S. boydii, relatively uncommon cause)
    • Group D (S. sonnei, leading diarrhea cause in high-income countries)
      • An outbreak in the UK and other European countries with XDR S. sonnei. The risk may be MSM, acquired as STD[3][23].
    • >46 serotypes mean insufficient protective immunity develops when exposed to new infections to prevent the next.
  • In clinical microbiology laboratories, MacConkey or EMB agar yields the best growth in addition to Shigella-Salmonella agar.

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MICROBIOLOGY

  • Aerobic Gram-negative rod (Fig), non-motile, non-spore-forming), family Enterobacteriaceae.
  • Four groups: subdivided into serotypes and subserotypes based upon lipopolysaccharide O antigenic repeats.
    • Group A (S. dysenteriae, see separate module for discussion of Group A infections, often cause of pandemics arising from natural and man-made disasters)
    • Group B (S. flexneri, leading cause in low- and middle-income countries)
    • Group C (S. boydii, relatively uncommon cause)
    • Group D (S. sonnei, leading diarrhea cause in high-income countries)
      • An outbreak in the UK and other European countries with XDR S. sonnei. The risk may be MSM, acquired as STD[3][23].
    • >46 serotypes mean insufficient protective immunity develops when exposed to new infections to prevent the next.
  • In clinical microbiology laboratories, MacConkey or EMB agar yields the best growth in addition to Shigella-Salmonella agar.

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Last updated: August 8, 2022