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- Sepsis (Greek, putrefaction): life-threatening organ dysfunction caused by host response to infection.
- Septic shock: subset of sepsis in which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than sepsis alone.
- Pathogens associated with site of antecedent infection: not comprehensive list
- Special populations
- Maternal and neonatal: Group B streptococci, E. coli.Group A streptococci (puerperal sepsis)
- Injection drug users: S. aureus, esp. MRSA
- Splenectomized or functionally asplenic pts: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Capnocytophaga canimorsus
- Neutropenic: GNB, Aspergillus.
- Traveler: malaria, salmonellosis.
- Healthy young adult: toxic shock syndromes (S. aureus or group A strep), N. meningitidis, bioterrorism (anthrax, plague), Hantavirus, severe influenza +/- bacterial superinfection.