- Malaria (acute) in combination with sulfadoxine and quinine in the treatment of chloroquine-resistant Plasmodium falciparum malaria.
- Resistance prevalent worldwide; not recommended as a prophylactic agent for travelers to most areas (not available in US).
- Toxoplasmosis (in combination with sulfadiazine OR clindamycin plus leucovorin).
Non-FDA approved uses
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