Johns Hopkins ABX GuideDiagnosisNeurologic

Prion Diseases

Trevor A. Crowell, M.D.
Prion Diseases is a topic covered in the Johns Hopkins ABX Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

PATHOGENS

  • Prions are abnormally folded versions of cell membrane proteins which are otherwise normally found throughout the human body.
    • Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemical and physical methods of inactivation.
    • Can induce conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
  • Prions cause transmissible spongiform encephalopathies (TSEs).

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: December 2, 2015