Prion Diseases
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PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
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PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
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