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- Some classify necrotizing fasciitis (NF) into Type I and Type II.
- Mixed aerobic-anaerobic bacteria [Type I]
- Group A Streptococcus (GAS, S. pyogenes, Type II)
- Thought to be the most common cause. CDC estimates ~ 700-1200 cases/yr annually since 2010.
- Certain Streptococcal strains are seen more frequently in NF, most commonly those that contain M protein types 1, 3, 12, and 28 (elaborating pyrogenic exotoxin A).
- May complicate routine varicella or zoster as superinfeciton.
- Other pathogens that may cause NF