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Lymphogranuloma venereum (LGV)

Lymphogranuloma venereum (LGV) is a topic covered in the Johns Hopkins ABX Guide.

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  • LGV due to Chlamydia trachomatis L1, L2 and L3 serovars.
  • All chlamydia, including those serovars causing LGV, are obligate intracellular Gram negative microorganisms but LGV serovars are lymphotrophic. Considered to cause systemic disease rather than superficial mucosal infection.
    • LGV is distinct from other chlamydia serovars causing either common genital chlamydial disease or trachoma.
    • LGV strains infect macrophages and spread to lymph nodes which is different from other C. trachomatis strains that are usually restricted to the the epithelial cells of the conjunctiva and urogenital mucosa. This tropism likely accounts for the differing clinical features and severity of LGV infection when compared with other strains.
  • The L2 serovar (and specifically the L2b strain) is the major cause of LGV outbreaks in the North America and Europe. L2b has been reported in at least 1 female partner of a bisexual male.

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Last updated: August 13, 2013


Hynes, Noreen A. "Lymphogranuloma Venereum (LGV)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2013. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540328/3.2/Lymphogranuloma_venereum__LGV_.
Hynes NA. Lymphogranuloma venereum (LGV). Johns Hopkins ABX Guide. The Johns Hopkins University; 2013. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540328/3.2/Lymphogranuloma_venereum__LGV_. Accessed July 20, 2019.
Hynes, N. A. (2013). Lymphogranuloma venereum (LGV). In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540328/3.2/Lymphogranuloma_venereum__LGV_
Hynes NA. Lymphogranuloma Venereum (LGV) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2013. [cited 2019 July 20]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540328/3.2/Lymphogranuloma_venereum__LGV_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Lymphogranuloma venereum (LGV) ID - 540328 A1 - Hynes,Noreen,M.D., M.P.H., D.T.M.&H. Y1 - 2013/08/13/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540328/3.2/Lymphogranuloma_venereum__LGV_ PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -