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Mycobacterium leprae

Paul G. Auwaerter, M.D., Valeria Fabre, M.D.
Mycobacterium leprae is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Acid fast bacillus (AFB) morphologically resembles tubercle bacillus.
    • M. leprae seen worldwide, but most common in Asia, Central and South America. Brazil, India, and Indonesia contribute 80% to the global new case load[21].
    • Newly identified species M. lepromatosis sp nov has been proposed as causing disseminated leprosy[9].
  • Slow-growing. Obligate intracellular pathogen, average doubling time ~2 weeks. Cannot culture in microbiology lab.
    • Armadillos and immunocompromised mice used to grow M. leprae for research purposes.

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Last updated: January 7, 2016

Citation

Auwaerter, Paul G, and Valeria Fabre. "Mycobacterium Leprae." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540310/all/Mycobacterium_leprae.
Auwaerter PG, Fabre V. Mycobacterium leprae. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540310/all/Mycobacterium_leprae. Accessed May 21, 2019.
Auwaerter, P. G., & Fabre, V. (2016). Mycobacterium leprae. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540310/all/Mycobacterium_leprae
Auwaerter PG, Fabre V. Mycobacterium Leprae [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 May 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540310/all/Mycobacterium_leprae.
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TY - ELEC T1 - Mycobacterium leprae ID - 540310 A1 - Auwaerter,Paul,M.D. AU - Fabre,Valeria,M.D. Y1 - 2016/01/07/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540310/all/Mycobacterium_leprae PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -