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Intravenous immune globulin
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- Bone marrow transplant (to prevent graft vs host disease)
- Primary immunoglobulin deficiency
- Idiopathic thrombocytopenia (ITP)
- Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended); Kawasaki disease.
- VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)
NON-FDA APPROVED USES
- Anemia due to parvovirus B19 infection.
- Non-FDA approved indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
- Non-FDA approved indications that is still controversial: patients with Strep TSS treated with IVIG had a trend toward a lower mortality rate.
- Severe C. difficile-associated colitis (based on case reports) .