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- Historically, three types of recombinant, subunit particle vaccines have been used, only 9-valent available in U.S. (2017):
- 9-valent (types 6, 11, 16, 18, 31, 33, 45, 52, 58)
- Quadrivalent (types 6, 11, 16, 18)
- Bivalent (types 16, 18)
- Vaccines contain virus-like particles (VLP) that do not contain genetic material, so they are non-infectious.