Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
- Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
- Genetic predisposition possible; 40% have family history of hidradentitis supperativa.
- Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and an infectious disease).
- Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis supperativa.
- Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
- Up to 50% of patients are culture negative.