Johns Hopkins ABX Guide
Hidradenitis Suppurativa
Hidradenitis Suppurativa is a topic covered in the Johns Hopkins ABX Guide.
To view the entire topic, please log in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
PATHOGENS
- Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
- Genetic predisposition possible; 40% have a family history of hidradenitis supperativa.
- Immune dysregulation in innate and adaptive immune pathways.
- Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and infectious disease).
- Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis suppurativa.
- Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
- Up to 50% of patients are culture negative.
-- To view the remaining sections of this topic, please log in or purchase a subscription --
PATHOGENS
- Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
- Genetic predisposition possible; 40% have a family history of hidradenitis supperativa.
- Immune dysregulation in innate and adaptive immune pathways.
- Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and infectious disease).
- Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis suppurativa.
- Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
- Up to 50% of patients are culture negative.
There's more to see -- the rest of this entry is available only to subscribers.
Last updated: September 27, 2019
Citation
Hoffmann, Christopher J. "Hidradenitis Suppurativa." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa.
Hoffmann CJ. Hidradenitis Suppurativa. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa. Accessed September 19, 2021.
Hoffmann, C. J. (2019). Hidradenitis Suppurativa. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa
Hoffmann CJ. Hidradenitis Suppurativa [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2021 September 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Hidradenitis Suppurativa
ID - 540272
A1 - Hoffmann,Christopher,M.D., M.P.H.
Y1 - 2019/09/27/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa
PB - The Johns Hopkins University
DB - Johns Hopkins Guide
DP - Unbound Medicine
ER -
