Johns Hopkins ABX Guide
Hidradenitis Suppurativa
Hidradenitis Suppurativa is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
- Genetic predisposition possible; 40% have a family history of hidradenitis supperativa.
- Immune dysregulation in innate and adaptive immune pathways.
- Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and infectious disease).
- Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis suppurativa.
- Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
- Up to 50% of patients are culture negative.
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PATHOGENS
- Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
- Genetic predisposition possible; 40% have a family history of hidradenitis supperativa.
- Immune dysregulation in innate and adaptive immune pathways.
- Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and infectious disease).
- Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis suppurativa.
- Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
- Up to 50% of patients are culture negative.
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Last updated: September 27, 2019
Citation
Hoffmann, Christopher J. "Hidradenitis Suppurativa." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa.
Hoffmann CJ. Hidradenitis Suppurativa. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa. Accessed August 17, 2022.
Hoffmann, C. J. (2019). Hidradenitis Suppurativa. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa
Hoffmann CJ. Hidradenitis Suppurativa [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2022 August 17]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Hidradenitis Suppurativa
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A1 - Hoffmann,Christopher,M.D., M.P.H.
Y1 - 2019/09/27/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540272/1/Hidradenitis_Suppurativa
PB - The Johns Hopkins University
DB - Johns Hopkins Guide
DP - Unbound Medicine
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