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Gas Gangrene is a topic covered in the Johns Hopkins ABX Guide.

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Common clostridial species causing gas gangrene:

  • Clostridium perfringens
    • Most commonly identified organism.
    • Produces > 20 exotoxins, including lethal Alpha and Beta toxins that cause necrosis and hemolysis.
  • Clostridium novyi  
  • Clostridium septicum  
  • Clostridium histolyticum  
  • Clostridium sordellii (seen with toxic shock after childbirth, users of contaminated heroin injections and patients with malignancy)
    • Review of spontaneous C. sordelli-associated gas gangrene found that known or occult malignancy was seen in 71% of the 94 patients in the literature; overall mortality was 67%[3].

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Last updated: August 9, 2019


Auwaerter, Paul G, and John G Bartlett. "Gas Gangrene." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene.
Auwaerter PG, Bartlett JG. Gas Gangrene. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene. Accessed August 21, 2019.
Auwaerter, P. G., & Bartlett, J. G. (2019). Gas Gangrene. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene
Auwaerter PG, Bartlett JG. Gas Gangrene [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 August 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene.
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TY - ELEC T1 - Gas Gangrene ID - 540239 A1 - Auwaerter,Paul,M.D. AU - Bartlett,John,M.D. Y1 - 2019/08/09/ BT - Johns Hopkins ABX Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540239/all/Gas_Gangrene PB - The Johns Hopkins University DB - Johns Hopkins Guide DP - Unbound Medicine ER -