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- Febrile neutropenia
- Fever: single oral temp ≥ 38.3°C (101°F) or temp ≥ 38°C (100.4°F) sustained for 1h AND
- Neutropenia: absolute neutrophil count (ANC) < 500 cells/mm3 OR ANC predicted to decrease to < 500 cells/mm3 in 48h
- Caveat: Signs and symptoms typical of bacterial infection (i.e., induration, erythema, pustulation, CXR infiltrates, CSF pleocytosis) may be absent, and course may be fulminant.