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- Member of Picornaviridae, (+) single strand RNA virus.
- Formerly classified as belonging to four groups (echoviruses, Coxsackie A, Coxsackie B and polioviruses), but now non-polio enteroviruses separated into Coxsackie A, Coxsackie B, echovirus and others (newly discovered enteroviruses named by consecutive number: e.g., EV70).
- Ubiquitous virus, totaling 62 non-polio enterovirus types: Group A Coxsackieviruses (1-22, 24), Group B Coxsackieviruses (1-6), Echoviruses (1-9, 11-21, 24-27, 29-33) and Enteroviruses (68-71).
- Believed to be second most common cause of human viral infection after rhinoviruses.