Johns Hopkins ABX Guide
Cytomegalovirus
MICROBIOLOGY
- A ubiquitous, large, enveloped dsDNA beta-herpesvirus that establishes lifelong latency after primary infection and exhibits significant genotypic diversity.[4]
- Cultured from urine, blood, throat, tears, stool, cervix, semen, and breast milk.
- Exhibits slow growth in cell culture.
- Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
- Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.[16]
- Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.[2]
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Last updated: March 5, 2022
Citation
Spacek, Lisa A. "Cytomegalovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
Spacek LA. Cytomegalovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus. Accessed September 23, 2023.
Spacek, L. A. (2022). Cytomegalovirus. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus
Spacek LA. Cytomegalovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2023 September 23]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540153/all/Cytomegalovirus.
* Article titles in AMA citation format should be in sentence-case
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