Cytomegalovirus

Lisa A. Spacek, M.D., Ph.D.
Cytomegalovirus is a topic covered in the Johns Hopkins ABX Guide.

To view the entire topic, please or .

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

-- The first section of this topic is shown below --

MICROBIOLOGY

  • A ubiquitous, large, enveloped dsDNA beta-herpesvirus that establishes lifelong latency after primary infection and exhibits significant genotypic diversity.[4]
  • Cultured from urine, blood, throat, tears, stool, cervix, semen, and breast milk.
  • Exhibits slow growth in cell culture.
    • Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
  • Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.[16]
  • Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.[2]

-- To view the remaining sections of this topic, please or --

MICROBIOLOGY

  • A ubiquitous, large, enveloped dsDNA beta-herpesvirus that establishes lifelong latency after primary infection and exhibits significant genotypic diversity.[4]
  • Cultured from urine, blood, throat, tears, stool, cervix, semen, and breast milk.
  • Exhibits slow growth in cell culture.
    • Detection of cytopathic effect in tissue culture can take up to 6 weeks and is characterized by large cells with nuclear (Cowdry owl’s eye) and cytoplasmic inclusions.
  • Isolation of the virus or detection of viral proteins or nucleic acid defines CMV infection.[16]
  • Presence of signs/symptoms of end-organ disease + CMV infection = CMV disease.[2]

There's more to see -- the rest of this entry is available only to subscribers.

Last updated: March 5, 2022