Johns Hopkins ABX Guide
Cefpodoxime proxetil
INDICATIONS
FDA
FDA
- Approved for the following mild-moderate bacterial infections:
- Upper respiratory tract infections, including acute otitis media, pharyngitis/tonsillitis,acute exacerbation of chronic bronchitis (AECB), and acute bacterial maxillary sinusitis
- Acute uncomplicated urethral and cervical gonorrhea and ano-rectal gonorrhea (females) caused by N. gonorrhoeae (no longer recommended by CDC)
- Uncomplicated skin and skin-structure infections S. aureus (MSSA) or S. pyogenes.
- Uncomplicated urinary tract infections caused by E. coli, K. pneumoniae, P. mirabilis, or S. saprophyticus.
- Community-acquired pneumonia (CAP) caused by S. pneumoniae or H. influenzae
- Uncomplicated gonorrhea (no longer recommended per CDC guideline)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Prophylaxis in neutropenic fever in patients who are intolerant of fluoroquinolones
- Oral alternative therapy for pyelonephritis without bacteremia in patients who are resistant to fluoroquinolones or trimethoprim/sulfamethoxazole.
- IDSA 2025 complicated UTI Guideline recommends:
- Complicated UTI (including acute pyelonephritis), avoid antibiotics to which the patient has had a resistant pathogen isolated from the urine previously
- For pylenephritis, including sepsis/shock, once clinically improved, can have an early transition from parenteral to oral therapy if such an.
- IDSA 2025 complicated UTI Guideline recommends:
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Last updated: March 8, 2026
Citation
Soto, Caitlin, and Edina Avdic. "Cefpodoxime Proxetil." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540098/0/Cefpodoxime_proxetil.
Soto C, Avdic E. Cefpodoxime proxetil. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540098/0/Cefpodoxime_proxetil. Accessed March 16, 2026.
Soto, C., & Avdic, E. (2026). Cefpodoxime proxetil. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540098/0/Cefpodoxime_proxetil
Soto C, Avdic E. Cefpodoxime Proxetil [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 March 16]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540098/0/Cefpodoxime_proxetil.
* Article titles in AMA citation format should be in sentence-case
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AU - Avdic,Edina,Pharm.D., BCPS
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BT - Johns Hopkins ABX Guide
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PB - The Johns Hopkins University
DB - Johns Hopkins Guides
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