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- Otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Staphylococci, and Streptococcus pyogenes
- Lower respiratory tract infections including pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus (author’s comment: not a first-line agent)
- Pharyngitis and tonsillitis caused by Streptococcus pyogenes (PCN is the drug of choice).
- Pyelonephritis and cystitis caused by Escherichia coli, Proteus mirabilis, Klebsiella spp., and coagulase-negative staphylococci (author’s comment: not a first-line agent)
- Skin and skin structure infections caused by Staphylococcus aureus (MSSA) and Streptococcus pyogenes