Burkholderia cepacia complex
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- Multi-species complex of bacteria, B. cepacia complex (Bcc) with species: B. cepacia, B. cenocepacia, B. multivorans, B. stablis, B. vietnamiensis, B. dolosa, B. ambifaria, B. lata, B. pyrrocinia.
- Known to produce secondary metabolites with antifungal and antimicrobial properties.
- Biosynthesis of antibiotics is controlled by quorum sensing, a global regulation system that coordinates bacteria behavior, allows cell-to-cell communication, and alters gene expression according to population density.
- Non-fermenting, aerobic Gram-negative rods. Originally described by Burkholder as causative agent of bacterial rot of onion bulbs (Latin, cepacia = onion).
- Waterborne, nosocomial, opportunistic pathogen. Ubiquitous in water, soil, plants. Patient-to-patient epidemic spread associated with increased mortality.
- Adheres to epithelial cells and mucin; survives inside epithelial cells and macrophages; forms biofilms; secretes catalases, proteases and siderophores.
- Formerly known as Pseudomonas cepacia.